The historic guesthouse
A character-rich private flat with space for up to seven guests, steps from South Grand and Tower Grove Park.
A higher standard of hospitality
Come as you are. Leave restored.
A cannabis-friendly sanctuary in a 120-year-old Tower Grove Heights flat—pairing the soul of a historic St. Louis home with thoughtful concierge service, local flavor and elevated wellness experiences.
4.97Guest rating
155Guest reviews
7 guestsEntire historic flat
Guest favorite
Superhost stay
Superhost stay
The Kalisto difference
Not just a room.
A stay shaped around you.
Private, welcoming and proudly 420-friendly, Kalisto House gives cannabis-experienced travelers—and the cannabis-curious—a respectful place to slow down.
Set just off South Grand, the second-floor guesthouse offers three bedrooms, two queen beds, a private balcony, kitchen, Wi-Fi, parking, laundry access and a shared fenced backyard. Your host’s local knowledge turns a comfortable stay into an easy St. Louis experience.
Build your stay
Choose your level of elevated.
Wellness upgrades
Ask about massage, Reiki, meditation-room setup and hot-tub access, subject to advance approval and availability.
Curated hospitality
Explore light breakfast provisions, infused dining experiences, special events and the Flower Cabinet through the concierge.
A stay with intention
Hospitality, with room to exhale.
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Concierge-led
Get local recommendations and help shaping a stay around food, wellness, events and responsible cannabis experiences.
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Cannabis-welcoming
A judgment-free setting for adults who value education, comfort and responsible use.
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Inclusive by nature
Family-friendly, pet-friendly and rooted in the diverse, walkable energy of Tower Grove Heights.
Tower Grove Heights
Stay local.
See more.
Walk to the restaurants, cafes, boutiques and international flavors of South Grand. Wander through Tower Grove Park, explore the Saturday farmers market or take a short ride to the Fox Theatre, City Museum, downtown and the Gateway Arch.
Plan a cannabis-friendly St. Louis trip~7 minwalk to Tower Grove Park
Steps awayfrom South Grand dining
~10 mindrive to downtown attractions
Local perksat select cannabis businesses
Explore before you arrive
Your guide to elevated St. Louis travel.
Cannabis bed & breakfast, St. LouisWhat makes a hosted 420-friendly stay different420-friendly lodging guideHow to choose respectful cannabis-friendly accommodationsCannabis wellness retreatsBuild a restorative, intention-led getawaySt. Louis cannabis tourismNeighborhoods, planning and responsible travelCannabis-friendly hotels in MissouriHotels, rentals and private guesthouses comparedPlant medicine retreat planningQuestions to ask before booking any experience
Know before you go
Good questions. Clear answers.
Is cannabis consumption allowed?
Kalisto House is cannabis-friendly and designed to provide adults a respectful setting for responsible use. Specific house rules, permitted areas and current Missouri law still apply. Confirm details with the host before arrival.
Is cannabis included with the reservation?
Do not assume cannabis is included. Ask the host about lawful, currently available concierge offerings. Guests must follow age requirements and all local and state laws.
What wellness services can I add?
Massage, Reiki, meditation-room setup and hot-tub access may be available as advance upgrades. Availability, pricing and provider terms are confirmed separately by the host.
Can I host a party or event?
Only with prior written permission and the applicable upgrade. Unauthorized parties are not allowed.
Is the guesthouse accessible?
The guesthouse is on the second floor, with steps up to the porch. Contact the host before booking to discuss specific mobility or accessibility needs.
Does Kalisto House provide medical treatment?
No. Hospitality and wellness experiences are not medical care, and nothing on this site is medical advice. Speak with a qualified clinician about health conditions, medications or cannabis-related risks.
Your St. Louis stay starts here